Lower limb ischemia sometimes lead to Critical limb ischemia (CLI) as seen in diabetic foot, burgers disease and others. Diabetic foot can also be due to diabetic neuropathy. The therapeutic potential of mesenchymal stem cell (MSC) transplantation for the treatment of ischemic conditions such as coronary artery disease, peripheral arterial disease, and stroke has been explored in animal models and early-phase clinical trials. A substantial database documents the safety profile of MSC administration to humans in a large number of disease states.
The mechanism of the therapeutic effect of MSC transplantation in ischemic disease has been postulated to be due to paracrine, immunomodulatory, and differentiation effects. Mesenchymal stem cells have also been shown to modulate neuropathy associated with this condition and improve blood supply (ischemia) in lower limbs when implanted into the limbs. If you want to try mesenchymal stem cells implantation then you may expect improvement in Pain, Ischemia, wound healing, prevention of amputation and gangrene formation etc We recommend you to first go through standard treatment available with your own doctors and if you are not satisfied with the outcome then only go for stem cell therapy .