Diabetes has increasingly become a worldwide health problem. Diabetes Type 1 is a chronic autoimmune disease that ultimately resulting in the loss of insulin production and secretion. Stem cell therapy, based on the generation of insulin-producing cells derived from MSCs, represents an attractive possibility and opened up new horizons to treatment of diabetes. Mesenchymal stem cells as another alternative source for cell replacement therapy in diabetes. Know more about stem cells therapy in diabetes mellitus.